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Type: Artigo de periódico
Title: The Genetics Of Blood Disorders: Hereditary Hemoglobinopathies
Author: De Sonati M.F.
Costa F.F.
Abstract: Objective: To summarize recently published data on the pathophysiology, diagnosis and treatment of sickle cell diseases and β-Thalassemias, the most relevant hereditary hemoglobinopathies in the global population. Sources: Searches were run on the MEDLINE and SCIELO databases, limited to the period from 2003 to May 2008, using the terms hereditary hemoglobinopathies, sickle cell diseases and β-thalassemia. Two books and two chapters were also included. Summary of the findings: More than 2,000 articles were identified; those providing the most important information and broadest views were selected. Conclusions: Morbidity and mortality rates from sickle cell diseases and β-thalassemia are still very high and represent an important challenge. Increased understanding of pathophysiological aspects has lead to significant improvements in treatment and prevention of these diseases. Copyright © 2008 by Sociedade Brasileira de Pediatria.
Rights: aberto
Identifier DOI: 10.2223/JPED.1802
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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