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Type: Artigo de periódico
Title: Synthesis And Characterization Of Inclusion Complex Of The Vasodilator Drug Minoxidil With β-cyclodextrin
Author: Calderini A.
Pessine F.B.T.
Abstract: The inclusion complex of β-cyclodextrin and minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide) was synthesized using two methods-kneading and freeze-drying-and characterized by UV-Vis spectroscopy, infrared spectroscopy, powder X-ray diffractometry, differential scanning calorimetry, thermal gravimetric analysis, and nuclear magnetic resonance spectroscopy. These techniques have demonstrated the existence of inclusion compound formation between the host and guest with a molar ratio of 1:1. The studies of solubility and the data obtained by nuclear magnetic resonance spectroscopy showed a weak interaction between the guest and the cyclodextrin molecules in solution. © 2007 Springer Science+Business Media B.V.
Rights: fechado
Identifier DOI: 10.1007/s10847-007-9387-z
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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