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Type: Artigo de periódico
Title: Topology Of A Ternary Complex (proparacaine-β-cyclodextrin - Liposome) By Std Nmr
Author: Cabeca L.F.
Fernandes S.A.
De Paula E.
Marsaioli A.J.
Abstract: The topologies of proparacaine (PPC) in β-cyclodextrin (β-CD), PPC in egg phosphatidylcholine (EPC) liposomes and PPC in β-CD in EPC were investigated using NMR experiments (1D ROESY and saturation transfer difference (STD)). This is the first description of the STD technique applied to PPC-EPC-β-CD system, revealing that not only PPC was imbedded in EPC bilayer, but β-CD was also interacting with liposome vesicles. These results are novel and were rationalized as the spontaneous formation of a ternary complex with some β-CD molecules bound to external liposome vesicles surfaces. Copyright © 2008 John Wiley & Sons, Ltd.
Rights: fechado
Identifier DOI: 10.1002/mrc.2265
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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