Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/106610
Type: Artigo de periódico
Title: Interaction Between Nitroheterocyclic Compounds With β-cyclodextrins: Phase Solubility And Hplc Studies
Author: de Melo N.F.S.
Grillo R.
Rosa A.H.
Fraceto L.F.
Abstract: Chagas disease is a serious health problem for Latin America. Nitrofurazone (NF) and Hidroxymethylnitrofurazone (NFOH) are active against Trypanosoma cruzi. The effect of β-cyclodextrin (β-CD) and dimethyl-β-cyclodextrin (DM-β-CD) complexation on the UV absorption and retention time of nitrofurazone (NF) and its hydroxymethylated analog (NFOH) were studied in solution. The retention behavior was analyzed on a reversed phase C18 column and the mobile phase used was acetonitrile-water (20/80 v/v), in which cyclodextrins (β-CD or DM-β-CD) were incorporated as a mobile phase additive. The decrease in the retention times of NF (or NFOH) with increasing concentration of HP-β-CD enables the determination of the complex stability constants by HPLC. A phase-solubility study was performed, according to the method reported by Higuchi and Connors, to evaluate the changes of NF/NFOH in the complexation state, and the diagrams obtained suggested that it forms complexes with a stoichiometry of 1:1. This is an important study for the characterization of potential formulations to be used as therapeutic options for the treatment of Chagas disease. © 2008 Elsevier B.V. All rights reserved.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/j.jpba.2008.04.022
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-44749094640&partnerID=40&md5=969a5a1b8fc91a4540ab0b4b2a7f87c4
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
2-s2.0-44749094640.pdf367.39 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.