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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.identifier.isbnnullpt
dc.typeArtigo de periódicopt_BR
dc.titleQuinolinate-induced Rat Striatal Excitotoxicity Impairs Endoplasmic Reticulum Ca2+-atpase Functionpt_BR
dc.contributor.authorFernandes A.M.A.P.pt_BR
dc.contributor.authorLandeira-Fernandez A.M.pt_BR
dc.contributor.authorSouza-Santos P.pt_BR
dc.contributor.authorCarvalho-Alves P.C.pt_BR
dc.contributor.authorCastilho R.F.pt_BR
unicamp.authorFernandes, A.M.A.P., Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), CP 6111, Campinas, SP 13083-887, Brazilpt_BR
unicamp.authorCastilho, R.F., Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), CP 6111, Campinas, SP 13083-887, Brazilpt_BR
unicamp.author.externalLandeira-Fernandez, A.M., Instituto de Bioquímica Médica, Universidade Federal Do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazilpt
unicamp.author.externalSouza-Santos, P., Instituto de Bioquímica Médica, Universidade Federal Do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazilpt
unicamp.author.externalCarvalho-Alves, P.C., Instituto de Bioquímica Médica, Universidade Federal Do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazilpt
dc.description.abstractExcessive activation of NMDA glutamate receptors and the resulting loss of intracellular Ca2+ homeostasis may be lethal (excitotoxic) to neurons. Such excitotoxicity can be induced in vivo by intrastriatal infusion of quinolinate, as this substance selectively activates NMDA receptors. The aim of the present research was to investigate whether the in vivo treatment of striatal tissue with quinolinate would lead to an early impairment of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity or mitochondrial Ca2+ sequestration, two intracellular mechanisms involved in Ca2+ homeostasis and signaling. Sodium quinolinate was infused intrastriatally into adult rats, and 6 h later the brains were removed and the corpora striata dissected. At this time point, striatal sections stained with Fluoro-Jade, a cellular marker of cell death, showed initial signs of neuronal degeneration. In addition, SERCA activity decreased 39% in relation to the activity observed in the control striata. A corresponding decrease of the same magnitude in 45Ca2+ uptake by striatal microsomes was also found in the treated striata. Western blot analysis did not indicate any decrease in SERCA levels in striatal tissue after quinolinate infusion. Mitochondrial Ca2+ sequestration was still preserved in quinolinate-treated striatal tissue when the assay was carried out in the presence of physiological concentrations of ATP and Mg2+. These results suggest that impairment of the SERCA function may be an early event in excitotoxicity. © 2008 Springer Science+Business Media, LLC.en
dc.relation.ispartofNeurochemical Researchpt_BR
dc.publishernullpt_BR
dc.date.issued2008pt_BR
dc.identifier.citationNeurochemical Research. , v. 33, n. 9, p. 1749 - 1758, 2008.pt_BR
dc.language.isoenpt_BR
dc.description.volume33pt_BR
dc.description.issuenumber9pt_BR
dc.description.initialpage1749pt_BR
dc.description.lastpage1758pt_BR
dc.rightsfechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn3643190pt_BR
dc.identifier.doi10.1007/s11064-008-9619-7pt_BR
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-48349109173&partnerID=40&md5=e0641997e6edaa789983cabade2d2137pt_BR
dc.date.available2015-06-30T19:31:08Z
dc.date.available2015-11-26T14:45:03Z-
dc.date.accessioned2015-06-30T19:31:08Z
dc.date.accessioned2015-11-26T14:45:03Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T14:45:03Z (GMT). No. of bitstreams: 1 2-s2.0-48349109173.pdf: 436854 bytes, checksum: 14d55f5e5146706cf22ef5b85ec136ad (MD5) Previous issue date: 2008en
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/106577
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/106577-
dc.identifier.idScopus2-s2.0-48349109173pt_BR
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