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Type: Artigo de periódico
Title: Acidocalcisomes In Apicomplexan Parasites
Author: Miranda K.
Souza W.d.
Plattner H.
Hentschel J.
Kawazoe U.
Fang J.
Moreno S.N.J.
Abstract: Acidocalcisomes are acidic calcium stores found in diverse organisms, being conserved from bacteria to man. They posses an acidic matrix that contains several cations bound to phosphates, mainly present in the form of short and long polyphosphate chains. Their matrix is acidified through the action of proton pumps such as a vacuolar proton ATPase and a vacuolar proton pyrophosphatase. The calcium uptake occurs through a Ca2+/H+ counter transporting ATPase located in the membrane of the organelle. Acidocalcisomes have been identified in a variety of microorganisms, including Apicomplexan parasites such as Plasmodium and Eimeria species, and in Toxoplasma gondii. In this paper, we review the structural, biochemical and physiological aspects of acidocalcisomes in Apicomplexan parasites and discuss their functional roles in the maintenance of intracellular ion homeostasis. © 2007.
Rights: fechado
Identifier DOI: 10.1016/j.exppara.2007.07.009
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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