Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/106447
Type: Artigo de periódico
Title: Phylogenetic Comparison Of The Carboxy-terminal Region Of Glycoprotein C (gc) Of Bovine Herpesviruses (bohv) 1.1, 1.2 And 5 From South America (sa)
Author: Esteves P.A.
Dellagostin O.A.
Pinto L.S.
Silva A.D.
Spilki F.R.
Ciacci-Zanella J.R.
Hubner S.O.
Puentes R.
Maisonnave J.
Franco A.C.
Rijsewijk F.A.M.
Batista H.B.C.R.
Teixeira T.F.
Dezen D.
Oliveira A.P.
David C.
Arns C.W.
Roehe P.M.
Abstract: Different types and subtypes of bovine herpesvirus 1 and 5 (BoHV-1 and BoHV-5) have been associated to different clinical conditions of cattle, in such a way that type/subtype differentiation has become an essential tool for understanding the pathogenesis and epidemiology of BoHV infections. In search for a genomic region that would allow a clear distinction between BoHV-1 and BoHV-5, the carboxy-terminal portion of glycoprotein C (gC), corresponding to residues 321-450 (BoHV-1) and 301-429 (BoHV-5) of 23 South American (SA) isolates (Brazil mostly) was amplified and sequenced. The nucleotide sequence alignments revealed levels of genomic similarity ranging from 98.7 to 99.8% among BoHV-1 isolates, 88.3 to 92% between BoHV-1/BoHV-5 and 96 to 99.7% among BoHV-5 isolates. At the amino acid level, sequence similarity varied ranging from 97.5 to 99.5% among BoHV-1, 77.5 to 84.4% between BoHV-1/BoHV-5 and 92.1 to 99.5% (BoHV-5/BoHV-5). The isolates could be clearly separated into BoHV-1.1, BoHV-1.2 and BoHV-5 after phylogenetic analysis. The results suggest that the phylogenetic analysis performed here can be used as a potential molecular epidemiological tool for herpesviruses. © 2007 Elsevier B.V. All rights reserved.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/j.virusres.2007.08.004
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-36849024984&partnerID=40&md5=79c27604f05656e325c597a7a07d9139
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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