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|Type:||Artigo de periódico|
|Title:||Inflammatory Activity Of Pelvic Ileal Pouches Mucosa In Asymptomatic Patients [processo Inflamatório Em Mucosa De Reservatórios Ileais De Doentes Assintomáticos]|
Ayrizono M. de L.S.
|Abstract:||Pouchitis after total retocolectomy is the most common complication in ulcerative colitis (UC). The immunological mechanisms involved in the genesis of pouchitis are unclear. Purpose: To evaluate STAT-1 activation and IFN-a expression in normal ileal pouch mucosa. Methods: Eighteen asymptomatic patients submitted to total retocolectomy and J pouch, were evaluated, being nine with UC and nine with FAP. The activation of STAT-1 and expressions of the cytokine were determined by immunoblot of total protein extracts from pouch mucosal biopsies. Results: STAT-1 activation was increased in UC, when compared to FAP and controls. Higher levels of IFN-γ expression were observed in UC when compared to control group, but was similar to FAP. Conclusions: These findings could explain a higher susceptibility to this inflammatory complication in UC when compared to FAP, which may be similar to UC disease.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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