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Type: Artigo de periódico
Title: Anacardic Acid Derivatives From Brazilian Propolis And Their Antibacterial Activity
Author: Silva M.S.S.
De Lima S.G.
Oliveira E.H.
Lopes J.A.D.
Chaves M.H.
Reis F.A.M.
Cito A.M.G.L.
Abstract: Propolis is a sticky, gummy, resinous substance collected by honeybees (Apis mellifera L.) from various plant sources, which has excellent medicinal properties. This paper describes the isolation and identification of triterpenoids and anacardic acid derivatives from Brazilian propolis and their antibacterial activity. Their structures were elucidated by 1H and 13C NMR, including uni- and bidimensional techniques; in addition, comparisons were made with data from academic literature. These compounds were identified as: cardanols (1a + 1b), cardols (2a + 2b), monoene anacardic acid (3), α-amirine (4), β-amirine (5), cycloartenol (6), 24-methylene- cycloartenol (7) and lupeol (8). The determination of the position of the double bond after a reaction with Dimethyl disulfide (DMDS) is described for the phenol derivatives. The ethanolic extract was tested in vitro for antimicrobial activity by using the disc diffusion method and it showed significant results against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Shigella spp.
Rights: aberto
Identifier DOI: 10.1590/S0100-46702008000300008
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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