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|Type:||Artigo de periódico|
|Title:||Physico-chemical Characterization Of Inclusion Complex Between Hydroxymethylnitrofurazone And Hydroxypropyl-β-cyclodextrin [caracterização Físico-química De Complexo De Inclusão Entre Hidroximetilnitrofurazona E Hidroxipropil-β- Ciclodextrina]|
De Melo N.F.S.
|Abstract:||Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-β-cyclodextrin (HP-β-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the inclusion complex between NFOH and HP-β-CD. The rate of NFOH release decreases after complexation and thermodynamic parameters from the solubility isotherm studies revealed that a stable complex is formed (ΔG° = - 1.7 kJ/mol). This study focuses on the physico-chemical characterization of a drug-delivery formulation that comes out as a potentially new therapeutic option for Chagas disease treatment.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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