Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/106168
Type: Artigo de periódico
Title: Physico-chemical Characterization Of Inclusion Complex Between Hydroxymethylnitrofurazone And Hydroxypropyl-β-cyclodextrin [caracterização Físico-química De Complexo De Inclusão Entre Hidroximetilnitrofurazona E Hidroxipropil-β- Ciclodextrina]
Author: Grillo R.
De Melo N.F.S.
Fraceto L.F.
Brito C.L.
Trossini G.H.G.
Menezes C.M.S.
Ferreira E.I.
Moraes C.M.
Abstract: Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-β-cyclodextrin (HP-β-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the inclusion complex between NFOH and HP-β-CD. The rate of NFOH release decreases after complexation and thermodynamic parameters from the solubility isotherm studies revealed that a stable complex is formed (ΔG° = - 1.7 kJ/mol). This study focuses on the physico-chemical characterization of a drug-delivery formulation that comes out as a potentially new therapeutic option for Chagas disease treatment.
Editor: 
Rights: aberto
Identifier DOI: 10.1590/S0100-40422008000200019
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-42149120174&partnerID=40&md5=596adc34c60933596f2343d18e41ee8c
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-42149120174.pdf342.68 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.