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|Type:||Artigo de periódico|
|Title:||Local Anesthetics: Interaction With Biological Membranes And With The Voltage-gated Sodium Channel [anestésicos Locais: Interação Com Membranas Biológicas E Com O Canal De Sódio Voltagem-dependente]|
|Author:||De Araujo D.R.|
De Paula E.
|Abstract:||Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the axon membranes, i.e. the voltage-gated sodium channel and the ones that take into account the interaction of anesthetic molecules with the lipid membrane phase for the reversible nerve blockage. Since there is a direct correlation between LA hydrophobicity and potency, it is crucial to take this physico-chemical property into account to understand the mechanism of action of LA, be it on the sodium channel protein, lipid(s), or on the whole membrane phase.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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