Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Local Anesthetics: Interaction With Biological Membranes And With The Voltage-gated Sodium Channel [anestésicos Locais: Interação Com Membranas Biológicas E Com O Canal De Sódio Voltagem-dependente]
Author: De Araujo D.R.
De Paula E.
Fraceto L.F.
Abstract: Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the axon membranes, i.e. the voltage-gated sodium channel and the ones that take into account the interaction of anesthetic molecules with the lipid membrane phase for the reversible nerve blockage. Since there is a direct correlation between LA hydrophobicity and potency, it is crucial to take this physico-chemical property into account to understand the mechanism of action of LA, be it on the sodium channel protein, lipid(s), or on the whole membrane phase.
Rights: aberto
Identifier DOI: 10.1590/S0100-40422008000700032
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-57749091344.pdf976.04 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.