Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/106160
Type: Artigo de periódico
Title: Local Anesthetics: Interaction With Biological Membranes And With The Voltage-gated Sodium Channel [anestésicos Locais: Interação Com Membranas Biológicas E Com O Canal De Sódio Voltagem-dependente]
Author: De Araujo D.R.
De Paula E.
Fraceto L.F.
Abstract: Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the axon membranes, i.e. the voltage-gated sodium channel and the ones that take into account the interaction of anesthetic molecules with the lipid membrane phase for the reversible nerve blockage. Since there is a direct correlation between LA hydrophobicity and potency, it is crucial to take this physico-chemical property into account to understand the mechanism of action of LA, be it on the sodium channel protein, lipid(s), or on the whole membrane phase.
Editor: 
Rights: aberto
Identifier DOI: 10.1590/S0100-40422008000700032
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-57749091344&partnerID=40&md5=e96db39df6df1c15e44a80ee95dc048e
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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