Please use this identifier to cite or link to this item:
Type: Artigo de evento
Title: Adrenoceptors And Adaptive Mechanisms In The Heart During Stress
Author: Spadari-Bratfisch R.C.
Dos Santos I.N.
Abstract: Several cardiovascular disorders have been related to alterations in beta-adrenoceptor (β-AR) signaling at or beyond the receptor level. During the stress reaction, the sympathetic-adrenal medullary system and the hypothalamus-pituitary-adrenal cortex axis are activated, causing β-AR overstimulation and remodeling of the β1/β2/ β3-AR ratio in cardiomyocytes. In a model of foot-shock stress, we described decreased β1-AR signaling occurring simultaneously with increased β2-AR signaling, whereas the response to the nonconventional agonist, CGP12177, was not altered. These alterations may play an adaptive role to the increased sympathetic drive to the heart, protecting the cardiac tissue from the cardiotoxic effects mediated by β1-ARs overstimulation without altering cardiac output, since this would be sustained by the β2-AR, which would also protect myocytes from apoptosis. Moreover, the selective enhancement of the β2-AR population might help to diminish the risk of overstimulation since this adrenoceptor subtype couples to both, stimulatory G (Gs) and inhibitory G (Gi) proteins. On the other hand, in the model of neurogenic hypertension, the decrease in β1-AR-mediated response is not followed by increase in the β2-AR-mediated response. However, the response to CGP12177, which was desensitized 48 h after the surgery, was normalized 7 days after that, when β1-AR were downregulated. Therefore, both experimental models provided evidence that the classical isoform of β1-AR and the recently described low-affinity isoform of β1-AR show independent behavior and provide the heart with adaptive mechanisms to increased sympathetic stimulation during stress. © 2008 New York Academy of Sciences.
Rights: fechado
Identifier DOI: 10.1196/annals.1410.075
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-57649171092.pdf244.07 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.