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Type: Artigo de periódico
Title: Ozonolysis Of Morita-baylis-hillman Adducts Originated From Aromatic Aldehydes: An Expeditious Diastereoselective Approach For The Preparation Of α,β-dihydroxy-esters
Author: Abella C.A.M.
Rezende P.
Lino de Souza M.F.
Coelho F.
Abstract: We disclose herein ozonolysis of Morita-Baylis-Hillman adducts originated from aromatic aldehydes. This efficient reaction provides α-ketoesters with different substitution patterns on the aromatic ring. Diastereoselective reduction of the corresponding α-ketoester obtained in the oxidative cleavage step provides α,β-dihydroxy-esters with excellent degree of anti diastereoselection. The method is simple and easy to execute and is therefore a valuable alternative to prepare either α-ketoesters or α,β-dihydroxy-esters. © 2007 Elsevier Ltd. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.tetlet.2007.10.149
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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