Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/106078
Type: Artigo de periódico
Title: The Use Of Growth Hormone To Treat Endocrine-metabolic Disturbances In Acquired Immunodeficiency Syndrome (aids) Patients [o Papel Do Hormônio De Crescimento No Tratamento Dos Distúrbios Endócrino-metabólicos Do Paciente Com A Síndrome Da Imunodeficiência Adquirida (aids)]
Author: Spinola-Castro A.M.
Siviero-Miachon A.A.
Da Silva M.T.N.
Guerra Jr. G.
Abstract: Acquired Immunodeficiency Syndrome (Aids) was initially related to HIV-associated wasting syndrome, and its metabolic disturbances to altered body composition. After Highly Active Antiretroviral Therapy (HAART ) was started, malnutrition has declined and HIV-associated lipodystrophy syndrome has emerged as an important metabolic disorder. Aids is also characterized by hormonal disturbances, principally in growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis. The use of recombinant human GH (hrGH) was formerly indicated to treat wasting syndrome, in order to increase lean body mass. Even though the use of hrGH in lipodystrophy syndrome has been considered, the decrease in insulin sensitivity is a limitation for its use, which has not been officially approved yet. Diversity in therapeutic regimen is another limitation to its use in Aids patients. The present study has reviewed the main HIV-related endocrine-metabolic disorders as well as the use of hrGH in such conditions. copyright© ABE&M todos os direitos reservados.
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Rights: aberto
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-51949110583&partnerID=40&md5=ed4ea6519c71a9a37ad784461182e5d4
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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