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Type: Artigo de periódico
Title: Serum Levels Of Interleukin-6 (il-6), Interleukin-18 (il-18) And C-reactive Protein (crp) In Patients With Type-2 Diabetes And Acute Coronary Syndrome Without St-segment Elevation [níveis Séricos De Interleucina-6 (il-6), Interleucina-18 (il-18) E Proteína C Reativa (pcr) Na Síndrome Coronariana Aguda Sem Supradesnivelamento Do St Em Pacientes Com Diabete Tipo 2]
Author: Souza J.R.M.
Oliveira R.T.
Blotta M.H.S.L.
Coelho O.R.
Abstract: Background: Atherosclerosis is an inflammatory disease, and serum levels of inflammatory markers such as interleukin 6 (IL-6), interleukin 18 (IL-18) and C-reactive protein (CRP) are used to evaluate patients with coronary artery disease. In patients with type-2 diabetes, atherosclerosis is related to a larger number of events such as myocardial infarction and death, when compared with patients without diabetes. Objective: To evaluate the inflammatory response in patients with diabetes and acute events of coronary instability. Methods: Two groups of patients were primarily selected. The first group was comprised of diabetic outpatients with stable angina (D-CCS) and presence of coronary artery disease on coronary angiography (n=36). The second group was comprised of diabetic patients seen in the emergency room with acute coronary syndrome (D-ACS) without ST-segment elevation (n=38). Non-diabetic patients with ACS (n=22) and CCS (n=16) comprised the control group. Serum levels of CRP, IL-6 and IL-18 were determined using nephelometry (CRP) and ELISA (IL-6 and IL-18) techniques. Results: Higher serum IL-6 levels were found in diabetic or non-diabetic patients with ACS than in the group with CCS. On the other hand, diabetic patients with ACS had higher CRP levels in comparison with the other groups. Serum IL-18 levels were not significantly different among the patients studied. Conclusion: our findings suggest a more intense inflammatory activity in patients with coronary instability. This inflammatory activity, as measured by CRP, seems to be even more intense in diabetic patients.
Rights: aberto
Identifier DOI: 10.1590/S0066-782X2008000200004
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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