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Type: Artigo de periódico
Title: L-name-induced Hypertension Does Not Completely Reproduce The Hemodynamic Pattern Of The Hypertensive-diabetic Cardiomyopathy In Rats
Author: Gazzoto A.
Sabha M.
Frigato V.
Ferreira-Melo S.E.
Bignotto L.M.
Lacchini R.
Tanus-Santos J.E.
Moreno Jr. H.
Abstract: Renovascular hypertension (2K1C) + type 1 diabetes mimics the morphological abnormalities described in the cardiomyopathy induced by L-NAME in rats, but their hemodynamic patterns are still controversial. The present study investigated the cardiovascular function in these two models of cardiomyopathy in rats after 8 weeks of treatment. Wistar rats were divided into the following groups: Control (C); L-NAME (L)-60 mg/kg/ day; 2K1C+DM (R+D)-streptozotocin (60 mg/kg) and one renal artery clipped. The following parameters were measured: mean arterial pressure (MAP), heart rate, cardiac output (CO) and total peripheral vascular resistance (TPVR). dP/dt+ and dP/dt- were also evaluated in an isolated heart setup. L and R+D groups had increased MAP (175.4±29.7 and 158.7±16.7 mmHg, respectively) and reduced CO after the 8th week. TPVR was increased in both groups. A decrease in dP/dt+ was found in the R+D (1895±98 mmHg/s, p<0.05) vs. C group (2534±120 mmHg/ s, p< 0.05). dP/dt- was diminished in the L and R+D groups vs. C group (1490±104 and 1460±94 mmHg/s, respectively vs. 2080±92 mmHg/s, p<0.05). Our study indicates that the hemodynamic abnormalities found in R+D and L-induced cardiomyopathies are not quite similar as well as their previously described histopathological features.
Rights: fechado
Identifier DOI: 
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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