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Type: Artigo de periódico
Title: The Inhibitors Of Tyrosine Kinase [os Inibidores De Tirosino Quinase De Segunda Geração]
Author: Delamain M.T.
Conchon M.
Abstract: Despite the success with imatinib as the first choice treatment of chronic myeloid leukemia (CML), there is still a subset of patients that do not respond optimally to or are intolerant of this drug or lose response. Imatinib resistance can occur at any phase, but it is more frequent in advanced phases, with mutations in the BCRABL kinase domain being the most common mechanism of resistance. More potent tyrosine kinase inhibitors have been developed that can overcome resistance to imatinib. Nilotinib and dasatinib are good examples of new tyrosine kinase inhibitors that are available. With these new agents, patients who develop imatinib resistance or those unable to tolerate imatinib treatment can achieve significant clinical responses.
Rights: aberto
Identifier DOI: 10.1590/S1516-84842008000500010
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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