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|Type:||Artigo de periódico|
|Title:||Estimation Of Absolute Renal Uptake With Technetlum-99m Dimercaptosuccinic Acid: Direct Comparison With The Radioactivity Of Nephrectomy Specimens|
|Author:||de Lima M. da C.L.|
de Lima M.L.
Santos A. de O.
Netto Jr. N.R.
|Abstract:||Context and Objective: Studies using radionuclides are the most appropriate method for estimating renal function. Dimercaptosuccinic acid chelate labeled with technetium-99m (99mTc-DMSA) is the radiopharmaceutical of choice for high-resolution imaging of the renal cortex and estimation of the functional renal mass. The aim of this study was to evaluate a simplified method for determining the absolute renal uptake (ARU) of 99mTc-DMSA prior to nephrectomy, using the radioactivity counts of nephrectomy specimens as the gold standard. Design and Setting: Prospective study at the Division of Nuclear Medicine, Department of Radiology, Universidade Estadual de Campinas. Methods: Seventeen patients (12 females; range 22-82 years old; mean age 50.8 years old) underwent nephrectomy for various reasons. Renal scintigraphy was performed three to four hours after intravenous administration of a mean dose of 188.7 MBq (5.1 mCi) of 99mTc-DMSA, which was done six to 24 hours before surgery. The in vivo renal uptake of 99mTc-DMSA was determined using the radioactivity of the syringe before the injection (measured using a dose calibrator) and the images of the syringe and kidneys, obtained from a scintillation camera. After surgery, the reference value for renal uptake of 99mTc-DMSA was determined by measuring the radioactivity of the nephrectomy specimen using the same dose calibrator. Results: The ARU measurements were very similar to those obtained using the reference method, as determined by linear regression (r-squared = 0.96). Conclusion: ARU estimation using the proposed method before nephrectomy seems to be accurate and feasible for routine use. Copyright © 2008, Associação Paulista de Medicina.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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