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Type: Artigo de periódico
Title: Antioxidant Supplementation And Premature Rupture Of The Membranes: A Planned Secondary Analysis
Author: Spinnato II J.A.
Freire S.
Pinto e Silva J.L.
Rudge M.V.C.
Martins-Costa S.
Koch M.A.
Goco N.
de Barros Santos C.
Cecatti J.G.
Costa R.
Ramos J.G.
Moss N.
Sibai B.M.
Abstract: Objective: The purpose of this study was to determine if antioxidant supplementation during pregnancy reduces the incidence of premature rupture of the membranes (PROM). Study Design: A placebo-controlled, double-blind trial was conducted. PROM and preterm PROM (PPROM) were planned secondary outcomes of the trial. Women between 120/7 and 196/7 weeks of gestation and diagnosed to have chronic hypertension or a prior history of preeclampsia were randomized to daily treatment with both vitamin C (1000 mg) and E (400 IU) or placebo. Results: Outcome data for PROM were available for 697 of 739 patients. The rates of PROM (37/349 [10.6%] vs 19/348 [5.5%]; adjusted risk ratio [RR] 1.89 [95.42% CI, 1.11-3.23]; P = .015), and PPROM (16/349 [4.6%] vs 6/348 [1.7%]; RR 2.68 [1.07-6.71]; P = .025) were increased in the antioxidant group. Conclusion: Contrary to expectations, vitamins C and E supplementation in this dose combination may be associated with an increased risk of PROM and PPROM. © 2008 Mosby, Inc. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.ajog.2008.07.011
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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