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|Type:||Artigo de periódico|
|Title:||Value Of Conventional Pap Smear, Liquid-based Cytology, Visual Inspection And Human Papillomavirus Testing As Optional Screening Tools Among Latin American Women < 35 And ≥ 35 Years Of Age: Experience From The Latin American Screening Study|
|Abstract:||Objective: To compare performance of conventional Pap test, liquid-based cytology (LBC) and visual inspection with acetic acid (VIA), as well as human papillomavirus (HPV) testing in 2 subcohorts of women, < 35 and ≥ 35 years of age. Study Design: Performance indicators were calculated using colposcopic biopsies as the gold standard; all results were corrected for verification bias using maximum likelihood. Results: Both conventional Pap test and Hybrid Capture 2 (HC2) assay performed significantly better among older women than younger; no difference was observed in performance of LBC and VIA, both inferior to Pap and HC2. The Pap test was more specific than HC2 in both subcohorts; HC2 had the highest sensitivity. For individual tests, the best balance between sensitivity and specificity was obtained for HC2 assay corrected for verification bias in the older women's subcohort; this was further improved by the combined use of the Pap test and HC2. Conclusion: Age of the target population is an important determinant of the performance of different screening tests. The choice of optimal test for women < 35 and ≥ 35 years of age depends on whether the highest positive predictive value (Pap test) or the best SE/SP balance (HC2) is used as the selection criterion. © The International Academy of Cytology.|
|Editor:||S. Karger AG|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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