Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/105223
Type: Artigo de periódico
Title: Preparation And Initial Characterization Of Inclusion Complex Between Nitrofurazone And 2-hydroxypropyl-β-cyclodextrin [preparação E Caracterização Inicial De Complexo De Inclusão Entre Nitrofurazona E 2-hidroxipropil-β-ciclodextrina]
Author: Melo N.F.S.
Grillo R.
Moraes C.M.
Brito C.L.
Trossini G.H.G.
Menezes C.M.S.
Ferreira E.I.
Rosa A.H.
Fraceto L.F.
Abstract: Nitrofurazone (NF), 5-nitro-2-furaldehyde semicarbazone, a broad-spectrum antibiotic, has reported toxic effects and low solubility in water. It would be of great interest to form inclusion complexes between NF and a cyclodextrin, to develop more effective and safer antibiotic formulations. This paper focuses on the preparation of inclusion complexes of NF with 2-hydroxypropyl-β- cyclodextrin (HP-β-CD) and their initial characterization by evaluating rates of complex formation, photostability, solubility isotherms, release rate profiles, stoichiometry of the complexes and their morphology, as revealed by scanning electron microscopy. The kinetic tests of complex formation revealed that 17,3 h is enough for stabilization of the NF-cyclodextrin complex. The solubility isotherm studies showed that the isotherm changes from type A to type B, as a function of temperature. The photostability experiments showed that the insertion of the NF in the HP-β-CD cavity protects the drug from photodecomposition. The release kinetic tests showed that the profile of NF release from the complex is altered by the presence of HP-β-CD in the medium. A Job's plot indicated that the stoichiometry of the complex was 1:1 NF:HP-β-CD. The scanning electron micrographs showed changes in the crystal structure of NF in the complex. This study focused on the physicochemical properties of drug-delivery formulations that could potentially be developed into a novel type of therapy with NF.
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Rights: aberto
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-39549087442&partnerID=40&md5=4cbbee4c3248ae488943ba65d54050a8
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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