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|Type:||Artigo de periódico|
|Title:||Plasmapheresis As A Therapy For Relapsed Focal Segmental Glomerulosclerosis (fsgs) After Kidney Transplantation: Case Report And A Review Of The Literature [plasmaférese Como Tratamento De Glomeruloesclerose Segmentar Focal (gesf) Recorrente Após Transplante Renal. Relato De Caso E Revisão Da Literatura]|
Marques Jr. J.F.C.
|Abstract:||Focal segmental glomerulosclerosis (FSGS) is a renal disease characterized by a nephrotic syndrome frequently evolving to endstage renal failure. At this stage, renal transplantation, using either cadaver or live donors, is the only therapeutic option. However, after renal transplantation relapse is high, at a rate of 50% on average. The cause seems to be related to a peripheral humoral factor responsible for increasing glomerular permeability. The clearance of this factor by apheresis is today considered a good therapeutic option. We describe the case of a 12-year-old male patient, with relapsed FSGS after renal transplantation, who was treated by plasmapheresis. After five procedures a sustained improvement in the renal function was obtained. Reports published on plasmapheresis for the treatment of FSGS before and after renal transplantation are still limited to short-term results involving a small number of patients. Some predictive factors for good responses were identified by several investigators including the early start of treatment after relapse and lower ages. The number of plasmapheretic procedures to reach remission varies widely, and should be determined on a case to case basis. Another possibility presented by some investigators is prophylactic plasmapheresis, but this still lacks evidence on efficacy. This case report is an example of FSGS with a good response to plasmapheretic procedures, showing a potential benefit of this treatment. However, further controlled studies involving a higher number of patients are necessary.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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