Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/105055
Type: Artigo de periódico
Title: High-performance Liquid Chromatographic Separation Of Rolipram, Bupivacaine And Omeprazole Using A Tartardiamide-based Stationary Phase. Influence Of Flow Rate And Temperature On The Enantioseparation
Author: da Silva Junior I.J.
Sartor J.P.
Rosa P.C.P.
de Veredas V.
Barreto Junior A.G.
Santana C.C.
Abstract: Chromatographic separation of the chiral drugs rolipram, bupivacaine and omeprazole on a tartardiamide-based stationary phase commercially named Kromasil CHI-TBB is shown in this work. The effect of temperature on the chromatographic separation of the chiral drugs using the Kromasil CHI-TBB stationary phase was determined quantitatively so as to contribute toward the design for the racemic mixtures of the named compound by using chiral columns. A decrease in the retention and selectivity factors was observed, when the column temperature increased. Van't Hoff plots provided the thermodynamic data. The variation of the thermodynamic parameters enthalpy and entropy are clearly negative meaning that the separation is enthalpy controlled. © 2007 Elsevier B.V. All rights reserved.
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Rights: fechado
Identifier DOI: 10.1016/j.chroma.2007.07.008
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-34547204517&partnerID=40&md5=ddf78fc7ea2b4d5c64b35e7c546de9a0
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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