Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/104949
Type: Artigo de periódico
Title: Diminished Myelin-specific T Cell Activation Associated With Increase In Ctla4 And Fas Molecules In Multiple Sclerosis Patients Treated With Ifn-β
Author: Hallal-Longo D.E.M.
Mirandola S.R.
Oliveira E.C.
Farias A.S.
Pereira F.G.
Metze I.L.
Brandao C.O.
Ruocco H.H.
Damasceno B.P.
Santos L.M.B.
Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the white matter of the central nervous system (CNS) characterized by focal areas of demyelination. Interferon-β (IFN-β) provides an effective treatment that lessens the frequency and severity of exacerbations in relapsing-remitting multiple sclerosis (RRMS), but the mechanisms by which IFN-β is efficient remain uncertain. The data presented here demonstrate that IFN-β impairs the proliferative response to myelin basic protein (MBP) and myelin, as well as increasing the expression of the CTLA4 intracellular molecule. Moreover, this treatment increases the expression of surface Fas molecules and of the soluble form of these molecules. Our hypothesis is that the increase in Fas and CTLA4 molecules in MS patients may lead to lymphocyte apoptosis, which suggests possible mechanisms underlying the therapeutic response to IFN-β. © 2007 Mary Ann Liebert, Inc.
Editor: 
Rights: fechado
Identifier DOI: 10.1089/jir.2007.0018
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-35648938148&partnerID=40&md5=00287f8fdc86647e73e292304a375224
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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