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Type: Artigo de evento
Title: Characterization Of Lidocaine:hydroxypropyl-β-cyclodextrin Inclusion Complex
Author: Moraes C.M.
Abrami P.
De Araujo D.R.
Braga A.F.A.
Issa M.G.
Ferraz H.G.
De Paula E.
Fraceto L.F.
Abstract: An inclusion complex was prepared between the local anesthetic lidocaine (LDC) and hydroxypropyl-β-CD (HP-β-CD). The complex was characterized by thermal analysis (differential scanning calorimetry, DSC), UV absorption and high-pressure liquid chromatography (HPLC). DSC results were indicative of complexation, due to the loss of the characteristic endothermic peak of LDC (77°C). Phase-solubility diagrams allowed the determination of the association constant between LDC and HP-β-CD (35.7 ± 4.7 M -1). The rate of LDC release decreased after complexation and thermodynamic parameters from the HPLC studies (ΔG° = -2.65 kJ/mol) revealed that a stable complex was formed. © 2007 Springer Science+Business Media, Inc.
Rights: fechado
Identifier DOI: 10.1007/s10847-006-9179-x
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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