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|Type:||Artigo de evento|
|Title:||Characterization Of Lidocaine:hydroxypropyl-β-cyclodextrin Inclusion Complex|
De Araujo D.R.
De Paula E.
|Abstract:||An inclusion complex was prepared between the local anesthetic lidocaine (LDC) and hydroxypropyl-β-CD (HP-β-CD). The complex was characterized by thermal analysis (differential scanning calorimetry, DSC), UV absorption and high-pressure liquid chromatography (HPLC). DSC results were indicative of complexation, due to the loss of the characteristic endothermic peak of LDC (77°C). Phase-solubility diagrams allowed the determination of the association constant between LDC and HP-β-CD (35.7 ± 4.7 M -1). The rate of LDC release decreased after complexation and thermodynamic parameters from the HPLC studies (ΔG° = -2.65 kJ/mol) revealed that a stable complex was formed. © 2007 Springer Science+Business Media, Inc.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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