Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Rapid Synapse Elimination After Postsynaptic Protein Synthesis Inhibition In Vivo
Author: McCann C.M.
Nguyen Q.T.
Neto H.S.
Lichtman J.W.
Abstract: To examine the role of retrograde signals on synaptic maintenance, we inhibited protein synthesis in individual postsynaptic cells in vivo while monitoring presynaptic terminals. Within 12 h, axon terminals begin to atrophy and withdraw from normal postsynaptic sites. Structural similarities between this process and naturally occurring synapse elimination suggest that short-lived target derived factors not only participate in synaptic maintenance in adults, but also regulate elimination of connections during development. Copyright © 2007 Society for Neuroscience.
Rights: fechado
Identifier DOI: 10.1523/JNEUROSCI.0627-07.2007
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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