Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/104692
Type: Artigo de periódico
Title: Cisplatin-induced Cytogenetic Alterations In V79 Cells
Author: Goncalves E.M.
Dos Santos M.T.
Bertoncelli M.D.F.
Bussamara G.A.
Fuzzari T.
Lima V.A.
Pesotte L.C.
Pitori V.
Genari S.C.
Abstract: Cisplatin is an antineoplastic agent used to treat solid malignancies, such as ovarian, testicular and bladder tumors. Studies have been shown that cisplatin induces genotoxic effects and chromosomal alterations that can result in genetic and chromosomal instability. In this work, we investigated the effects of cisplatin on the cytogenetic traits of cultured V79 cells based on the modal chromosome number, mitotic index, frequency of polyploidy and number of aneuploid metaphases. Cisplatin-treated V79 cells showed an altered chromosome number distribution, as well as an enhanced mitotic index, frequency of polyploidy and number of aneuploid metaphases. These alterations were probably related to the genetic instability produced by cisplatin. In addition, these cells showed characteristics associated with neoplastic development that corresponded to neoplastic processes related to the use of cisplatin in chemotherapy. © 2007 The Japan Mendel Society.
Editor: 
Rights: aberto
Identifier DOI: 10.1508/cytologia.72.155
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-34548297906&partnerID=40&md5=7e67bc2e46750ef6ffc3dc6813b5a368
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-34548297906.pdf258.08 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.