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|Type:||Artigo de periódico|
|Title:||Association Between Age At First Sexual Intercourse And Subsequent Human Papillomavirus Infection: Results Of A Brazilian Screening Program [associação Entre Idade Ao Início Da Atividade Sexual E Subsequente Infecção Por Papilomavírus Humano: Resultados De Um Programa De Rastreamento Brasileiro]|
De Matos J.C.
|Abstract:||PURPOSE: to investigate women's age at their first sexual intercourse and its correlation with their present age, human papillomavirus (HFV] infection and cylological abnormalities at Pap smear. METHODS: women from the general population were invited to be screened for cervical cancer and pre-malignant lesions. After answering a behavior questionnaire, they were submitted lo screening with cervical cytology and high-risk HPV testing with Hybrid Capture 2 (HC2). This report is part of the Latin American Screening (LAMS) study, that comprises centers from Brazil and Argentina, and the data presented herein refer to the Brazilian women evaluated at the cities of Porto Alegre, São Paulo and Campinas. RESULTS: from 8,049 women that answered the questionnaire, 8,041 reported previous sexual activity and were included in this analysis. The mean age at the interview was 38.1±11.0 years and the mean age at the first sexual intercourse was 18.5±4.0 years. The age at the first sexual intercourse increased along with the age at the interview, i.e., younger women reported they had begun their sexual life earlier than older women (p<0.001). From the total of women who had already begun having sexual intercourse, 3,043 patients were tested for high-risk HPV infection and 17.3% of them had positive results. In all the centers, it became clear that the women with the first sexual intercourse at ages below the mean age of all the population interviewed presented higher rates of HPV infection (20.2%) than the women with the first sexual intercourse at ages above the mean (12.5%) - Odds Ratio (OR) 1.8 (IC95% 1.5-2.2;p<0,001). According to the cytology, the women with first sexual intercourse at ages under the mean, presented higher percentage of abnormal cytology ≥ASC-US (0.7%) than the women with the first sexual intercourse at ages above the mean (4.3%) - OR 1.6 (IC95% 1.3-2.;p<0.001). CONCLUSIONS: the high-risk HPV infection and cylological abnormalities identified during the asymptomatic population screening were significantly associated to the women's age at the first sexual intercourse. Additionally, we have also identified that the women's age at the first sexual intercourse has decreased during the last decades, suggesting an important contribution to the increase of HPV infection and the subsequent cervical lesions.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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