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|Type:||Artigo de periódico|
|Title:||Preparation And Physico-chemical Characterization Of Inclusion Complexes Between Local Anesthetics And Hydroxypropyl-β-cyclodextrin [preparação E Caracterização Físico- Química De Complexos De Inclusão Entre Anestésicos Locais E Hidroxipropil-β-ciclodextrina]|
De Paula E.
|Abstract:||S(-) Bupivacaine (S(-)BVC) and Lidocaine (LDC) are widely used local anesthetics (LA). Hydroxypropyl β-cyclodextrin (HP-β-CD) is used as a drug-carrier system. The aim of this work was to characterize inclusion complexes between LA and HP-β-CD. The affinity constants determined at different pHs show favourable complexation. The release kinetics experiments showed that S(-)BVC and LDC changed the released profiles in the presence of HP-β-CD. Nuclear magnetic resonance experiments gave information about the interaction between LA and the cyclodextrin cavity. This study focused on the physicochemical characterization of drug-delivery formulations that come out as potentially new therapeutic options for pain treatment.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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