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Type: Artigo de periódico
Title: Preparation And Physico-chemical Characterization Of Inclusion Complexes Between Local Anesthetics And Hydroxypropyl-β-cyclodextrin [preparação E Caracterização Físico- Química De Complexos De Inclusão Entre Anestésicos Locais E Hidroxipropil-β-ciclodextrina]
Author: Moraes C.M.
Abrami P.
Goncalves M.M.
Filho N.A.
Fernandes S.A.
De Paula E.
Fraceto L.F.
Abstract: S(-) Bupivacaine (S(-)BVC) and Lidocaine (LDC) are widely used local anesthetics (LA). Hydroxypropyl β-cyclodextrin (HP-β-CD) is used as a drug-carrier system. The aim of this work was to characterize inclusion complexes between LA and HP-β-CD. The affinity constants determined at different pHs show favourable complexation. The release kinetics experiments showed that S(-)BVC and LDC changed the released profiles in the presence of HP-β-CD. Nuclear magnetic resonance experiments gave information about the interaction between LA and the cyclodextrin cavity. This study focused on the physicochemical characterization of drug-delivery formulations that come out as potentially new therapeutic options for pain treatment.
Rights: aberto
Identifier DOI: 
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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