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Type: Artigo de periódico
Title: Characterization Of The Inclusion Complex Ropivacaine: β-cyclodextrin [caracterização Do Complexo De Inclusão Ropivacaína: β-ciclodextrina]
Author: Fraceto L.F.
Goncalves M.M.
Moraes C.M.
De Araujo D.R.
Zanella L.
De Paula E.
Pertinhez T.D.A.
Abstract: Ropivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with β-cyclodextrin (β-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:β-CD complex by nuclear magnetic resonance (NMR). The stoichiometry of the complex is 1:2 RVC:β-CD. DOSY-NMR shows that the association constant is 55.5 M-1. Longitudinal relaxation time results show that RVC changes its mobility in the presence of β-CD. This study is focused on the physicochemical characterization of inclusion complexes that are potentials options for pain treatment.
Rights: aberto
Identifier DOI: 
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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