Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/104435
Type: Artigo de periódico
Title: Screening Protein-ligand Interactions Using 1h Nmr Techniques For Detecting The Ligand [mapeamento Das Interações Proteína-ligante Através De Técnicas De Rmn De1h Utilizando Detecção Do Ligante]
Author: Figueiredo I.M.
Marsaioli A.J.
Abstract: NMR is a valuable screening tool for the binding of ligands to proteins providing structural information on both protein and ligands and is thus largely applied to drug-discovery. Among the recent NMR techniques to probe weak binding protein-ligand complexes we have critically evaluated the advantages and disadvantages of STD (Saturation Transfer Difference), WaterLOGSY (Water Ligand Observation with Gradient Spectroscopy), NOE pumping and DOSY-NOESY (Diffusion-Ordered NOESY) using a mixture of BSA (bovine serum albumin) plus salicylic acid, caffeine, citric acid, adipic acid and D-glucose.
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Rights: aberto
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-40849096067&partnerID=40&md5=0183169ef8b9230f4a270efce3955343
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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