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Type: Artigo de periódico
Title: Lipid Profile And Cardiovascular Risk In A Population Of Elderly Women With Subclinical Hipothyroidism [perfil Lipídico E Risco Cardiovascular Em Mulheres Idosas Portadoras De Hipotiroidismo Subclínico]
Author: Peterson J.C.B.
Guariento M.E.
Abstract: Subclinical hypothyroidism (SCHT) is a disease characterized by an increase in the thyrostimulating hormone (TSH), which is associated to normal levels of free thyroxin (FT4), which frequently does not present signs and symptoms of clinically manifested hypothyroidism. Literature reports a higher prevalence in women and elderly people. In this work, 76 elderly women with SCHT were studied in the Endocrinology Clinic of FMJ - Jundiaí (São Paulo, Brazil), excluding patients in treatment to hypothyroidism and who presented other endocrinopathy or conditions that cause dyslipidemia. They were analyzed according to: Age (Average ± OR): (70.43±4.84), BMI (27.52±3.07), Systolic Blood Pressure (136.97±17.44), Diastolic Blood Pressure (87.89±10.87), FT4 (1.28±0.25), TSH (12.41±11.19), Total Cholesterol (TC) (257.12±61.22), HDL-c (39.30±8.78), LDL-c (146.49±42.94), VLDL-c (41.13±27.41) and Triglycerides (224.46±123.30). The clinical-laboratorial profiles present in this group was carried out through the clusters' comparative analysis, demonstrating the existence of two profiles: 1. Higher levels of FT4 and HDL-c and lower levels of TSH, CT, TG, LDL-c, VLDL-c, CT/HDL-c and LDL/HDL-c; 2. Lower levels of FT4 and HDL-c and higher levels of TSH, CT, TG, LDL-c, VLDL-c, CT/HDL-c and LDL/HDL-c. The apparent relationship between SCHT and dyslipidemia resulted in a high CT/HDL-c (p<0.001) and LDL-c/HDL-c (p<0.001) ratios in subgroup 2, which implies in increased cardiovascular risk, due to atherosclerotic vascular disease (AVD). In conclusion, this study relates SCHT with dyslipidemia in a group of elderly women, revealing two endocrine-metabolic profiles, in which that with smaller FT4 and HDL-c levels presents a higher risk of developing atherosclerosis. © Copyright Moreira Jr. Editora.
Rights: fechado
Identifier DOI: 
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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