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|Type:||Artigo de periódico|
|Title:||Comparative Study Of The Efficacy And Safety Of Valdecoxib And Piroxicam In The Treatment Of Patients With Primary Dysmenorrhea [comparação Da Eficácia E Segurança De Valdecoxibe* E Piroxicam No Tratamento Da Dismenorréia Primária]|
Isaia Filho C.
De Oliveira H.C.
|Abstract:||Introduction: Dysmenorrhea is described as a moderate or severe pain experienced during or immediately before menstruation and it can cause an alteration of women daily activities. Objective: To compare the efficacy and safety of valdecoxib, piroxicam, or placebo in the treatment of patients with primary dysmenorrhea. Methods: A total of 169 subjects were included in this multicenter, double blind, randomized study, to evaluate comparative of efficacy and safety of valdecoxib (Group 1) 40 mg bis a day (first day), and 40 mg once a day for two days in the first menstrual cycle and piroxicam 40 mg once a day for three days another cycle, versus piroxicam (Group 2) 40 mg once day for three days on the first menstrual cycle and valdecoxib 40 mg twice on the first day and once for two days another cycle. Both the groups were compared with placebo group, for two cycles. The efficacy was evaluated by pain relief calculated as the summed weighted pain relief scores to 8 hours (TOTPAR 8h). The SPID 8h, percent of subjects who took rescue medication and percent of subjects who took the second dose of study medication were used to mesure the secondary efficacy. Safety was assessed by adverse events reported by patients of the groups. Results and conclusions: The results of this study showed that valdecoxib is as effective as piroxicam to treat severe pain in women with primary dysmenorrhea. The safety profile of the two drugs was similar, and no serious adverse events was recorded during the study. © Copyright Moreira Jr. Editora.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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