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Type: Artigo de periódico
Title: Vernonia Polyanthes As A New Source Of Antiulcer Drugs
Author: Barbastefano V.
Cola M.
Luiz-Ferreira A.
Farias-Silva E.
Hiruma-Lima C.A.
Rinaldo D.
Vilegas W.
Souza-Brito A.R.M.
Abstract: Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action. © 2007 Elsevier B.V. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.fitote.2007.07.003
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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