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Type: Artigo de periódico
Title: Efficient Heck Arylations Of Cyclic And Acyclic Acrylate Derivatives Using Arenediazonium Tetrafluoroborates. A New Synthesis Of The Antidepressant Drug (±)-paroxetine
Author: Pastre J.C.
Correia C.R.D.
Abstract: The Heck arylation of acyclic- and cyclic-substituted acrylates using several arenediazonium tetrafluoroborates was investigated. Arylations were carried out under aerobic, ligand-free conditions to provide the corresponding substituted acrylates in moderate to high isolated yields. Heck arylations were usually completed in less than 2 h in refluxing methanol. The aza-endocyclic acrylate derivative 11a was converted into the antidepressant drug (±)-paroxetine in a concise new route in good overall yield. © 2006 American Chemical Society.
Rights: fechado
Identifier DOI: 10.1021/ol060248e
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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