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Type: Artigo de evento
Title: Kinetic Modeling Of Cell Death By Shear Stress Of A Hybridoma Culture In A Sparged And Stirred Bioreactor
Author: De Gouveia T.
Lee C.Y.
Tamashiro W.M.S.C.
Augusto E.D.F.P.
Bonomi A.
Abstract: In animal cell systems, cell death by shear stress is an important factor to be considered when defining the required sparging and agitation to maintain the dissolved oxygen concentration and the homogeneity of the bioreactor. This paper presents the effects of air sparging and agitation in an ideal bioreactor configuration for animal cell culture. In these conditions, the effect of agitation on the cell death rate is negligible and this parameter can be considered directly proportional to the superficial gas rate.
Rights: aberto
Identifier DOI: 
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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