Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/103808
Type: Artigo de periódico
Title: The Application Of Flow Cytometric Analysis Of Bone Marrow Cells For The Diagnosis And Prognosis Of Myelodysplastic Syndromes [contribuição Da Citometria De Fluxo Para O Diagnóstico E Prognóstico Das Síndromes Mielodisplásicas]
Author: Lorand-Metze I.
Abstract: The diagnosis of MDS is based on the presence of peripheral cytopenias together with cell atypias in bone marrow precursors and cytogenetic abnormalities. However, in several cases, the cell atypias are discrete, and/or the karyotype is normal, precluding a clear-cut diagnosis. Multiparametric flow cytometry is a fast, reproducible and relatively inexpensive technique, which is able to disclose changes in the expression of lineage and maturation related antigens. Several of such abnormalities have been described in MDS. Three or four-color protocols have been used to analyze erythroblasts, granulocytes, monocytes and blasts, permitting, in most of the cases, the differential diagnosis between MDS and non-clonal disorders presenting pancytopenia. Flow cytometry is also useful in the follow-up of the patients, since it has been described that progression of the MDS clone is accompanied by an increase in the number of phenotypic abnormalities and of CD34+ cells, as well as the decrease in pro-apoptotic markers in bone marrrow cells.
Editor: 
Rights: aberto
Identifier DOI: 10.1590/S1516-84842006000300005
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-33846931510&partnerID=40&md5=15c378eda671548b3deb85b5f36ff263
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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