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Type: Artigo de periódico
Title: Mitochondrial Ca2+ Transport, Permeability Transition And Oxidative Stress In Cell Death: Implications In Cardiotoxicity, Neurodegeneration And Dyslipidemias
Author: Vercesi A.E.
Kowaltowski A.J.
Oliveira H.C.F.
Castilho R.F.
Abstract: Mitochondrial Ca2+ transport is important in the maintenance of intracellular ion homeostasis, and also a key factor in the pathogenesis of many diseases. We discuss here the main aspects of mitochondrial Ca2+ transport, and how this transport is linked to changes in energy metabolism and redox state. Mitochondrial permeability transition, a consequence of excessive mitochondrial Ca2+ accumulation associated with oxidative stress is also discussed. Finally, our current understanding of the involvement of these mitochondrial processes in cardiac ischemia-reperfusion, neurodegeneration and dyslipidemias is presented.
Rights: fechado
Identifier DOI: 10.2741/1990
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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