Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/103679
Type: Artigo de periódico
Title: Mitochondrial Ca2+ Transport, Permeability Transition And Oxidative Stress In Cell Death: Implications In Cardiotoxicity, Neurodegeneration And Dyslipidemias
Author: Vercesi A.E.
Kowaltowski A.J.
Oliveira H.C.F.
Castilho R.F.
Abstract: Mitochondrial Ca2+ transport is important in the maintenance of intracellular ion homeostasis, and also a key factor in the pathogenesis of many diseases. We discuss here the main aspects of mitochondrial Ca2+ transport, and how this transport is linked to changes in energy metabolism and redox state. Mitochondrial permeability transition, a consequence of excessive mitochondrial Ca2+ accumulation associated with oxidative stress is also discussed. Finally, our current understanding of the involvement of these mitochondrial processes in cardiac ischemia-reperfusion, neurodegeneration and dyslipidemias is presented.
Editor: 
Rights: fechado
Identifier DOI: 10.2741/1990
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-33744492597&partnerID=40&md5=2c391498fb8a221f01ccee3890f229dc
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.