Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/103624
Type: Artigo de periódico
Title: Antiulcerative Properties Of Bovine α-lactalbumin
Author: Mezzaroba L.F.H.
Carvalho J.E.
Ponezi A.N.
Antonio M.A.
Monteiro K.M.
Possenti A.
Sgarbieri V.C.
Abstract: The capacity of α-lactalbumin to protect the rat stomach mucosa against ulcerative lesions caused by indomethacin or absolute ethanol was investigated. An α-lactalbumin prepared in the laboratory by anion exchange and molecular exclusion chromatography (Lab.α-La) and a commercial α-lactalbumin (Comm.α-La) were compared with a saline control. Comm.α-La offered 44% protection versus Lab.α-La 12%, in the indomethacin model. For absolute ethanol, no statistical difference was found in the inhibition of the development of ulcerative lesions for the two α-lactalbumins, ranging from 32% to 50%. The content of prostaglandin E2 (PGE2) and mucus increased in the mucosa after α-La intubation, suggesting that the protein protects the mucosa via stimulation of PGE2 and mucus production. Blocking free sulfhydryl groups by in vivo N-ethylmaleimide alkylation caused an increase in mucosal ulcerative lesions, suggesting the importance of sulfhydryl compounds in the gastric mucosa protection. © 2006 Elsevier Ltd. All rights reserved.
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Rights: fechado
Identifier DOI: 10.1016/j.idairyj.2005.10.027
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-33646519009&partnerID=40&md5=88cdc8870fc08c3afa4a7f5bba064489
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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