Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/103617
Type: Artigo
Title: High- or low-salt diet from weaning to adulthood: effect on body weight, food intake and energy balance in rats
Author: Heimann J.C.
Coelho M.S.
Furukawa L.L.
Passadore M.D.
Prada P.O.
Gasparetti A.L.
Bibancos T.
Furukawa L.N.S.
Casarini D.E.
Fukui R.T.
Dolnikoff M.S.
Luz J.J.
Chiavegatto S.
Saad M.J.A.
Abstract: Objective: To get some additional insight on the mechanisms of the effect of salt intake on body weight. Design and methods: Rats were fed a low (LSD), normal (NSD), or high (HSD) salt diet. In a first set, body weight, tail-cuff blood pressure, fasting plasma thyroid-stimulating hormone, triiodothyronine, L-thyroxine, glucose, insulin, and angiotensin II were measured. Angiotensin II content was determined in white and brown adipose tissues. Uncoupling protein 1 expression was measured in brown adipose tissue. In a second set, body weight, food intake, energy balance, and plasma leptin were determined. In a third set of rats, motor activity and body weight were evaluated. Results: Blood pressure increased on HSD. Body weight was similar among groups at weaning, but during adulthood it was lower on HSD and higher on LSD. Food intake, L-thyroxine concentration, uncoupling protein 1 expression and energy expenditure were higher in HSD rats, while non-fasting leptin concentration was lower in these groups compared to NSD and LSD animals. Plasma thyroid-stimulating hormone decreased on both HSD and LSD while plasma glucose and insulin were elevated only on LSD. A decrease in plasma angiotensin II was observed in HSD rats. On LSD, an increase in brown adipose tissue angiotensin II content was associated to decreased uncoupling protein 1 expression and energy expenditure. In this group, a low angiotensin II content in white adipose tissue was also found. Motor activity was not influenced by the dietary salt content. Conclusions: Chronic alteration in salt intake is associated with changes in body weight, food intake, hormonal profile, and energy expenditure and tissue angiotensin II content. © 2005 Elsevier B.V. All rights reserved.
To get some additional insight on the mechanisms of the effect of salt intake on body weight. design and methods: rats were fed a low (LSD), normal (NSD), or high (HSD) salt diet. In a first set, body weight, tail-cuff blood pressure, fasting plasma thyroid-stimulating hormone, triiodothyronine, L-thyroxine, glucose, insulin, and angiotensin II were measured. angiotensin II content was determined in white and brown adipose tissues. Uncoupling protein 1 expression was measured in brown adipose tissue. In a second set, body weight, food intake, energy balance, and plasma leptin were determined. In a third set of rats, motor activity and body weight were evaluated. Results: Blood pressure increased on HSD. body weight was similar among groups at weaning, but during adulthood it was lower on HSD and higher on LSD. Food intake, L-thyroxine concentration, uncoupling protein 1 expression and energy expenditure were higher in HSD rats, while non-fasting leptin concentration was lower in these groups compared to NSD and LSD animals. Plasma thyroid-stimulating hormone decreased on both HSD and LSD while plasma glucose and insulin were elevated only on LSD. A decrease in plasma angiotensin II was observed in HSD rats. On LSD, an increase in brown adipose tissue angiotensin II content was associated to decreased uncoupling protein 1 expression and energy expenditure. In this group, a low angiotensin II content in white adipose tissue was also found. Motor activity was not influenced by the dietary salt content. Conclusions: Chronic alteration in salt intake is associated with changes in body weight, food intake, hormonal profile, and energy expenditure and tissue angiotensin II content
Subject: Peso corporal
Metabolismo energético
Hormônios
Country: Itália
Editor: Medikal Press
Citation: Nutrition, Metabolism And Cardiovascular Diseases. , v. 16, n. 2, p. 148 - 155, 2006.
Rights: fechado
Identifier DOI: 10.1016/j.numecd.2005.09.001
Address: https://www.sciencedirect.com/science/article/pii/S0939475305001705?via%3Dihub
Date Issue: 2006
Appears in Collections:FCM - Artigos e Outros Documentos

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