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|Type:||Artigo de periódico|
|Title:||Antiproliferative Effect Of baylis-hillman Adducts And a new Phthalide Derivative On human Tumor Cell Lines|
De Carvalho J.E.
|Abstract:||In this work we report our results concerning the study on the in vitro antiproliferative activity of 18 Baylis-Hillman adducts and some derivatives against a panel of humor tumor cell lines. A brief qualitative structure-activity relationship study indicated that carbon-carbon double bond and the presence of an electron-withdrawing substituent at the aromatic ring are essential for the activity. A quinoline-phthalide derivative has exhibited a potent effect on the proliferation of all cell lines. It is interesting to note their special cytotoxic activity against NCIADR cell line. © 2006 Elsevier SAS. All rights reserved.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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