Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/103470
Type: Artigo de periódico
Title: Antiproliferative Effect Of baylis-hillman Adducts And a new Phthalide Derivative On human Tumor Cell Lines
Author: Kohn L.K.
Pavam C.H.
Veronese D.
Coelho F.
De Carvalho J.E.
Almeida W.P.
Abstract: In this work we report our results concerning the study on the in vitro antiproliferative activity of 18 Baylis-Hillman adducts and some derivatives against a panel of humor tumor cell lines. A brief qualitative structure-activity relationship study indicated that carbon-carbon double bond and the presence of an electron-withdrawing substituent at the aromatic ring are essential for the activity. A quinoline-phthalide derivative has exhibited a potent effect on the proliferation of all cell lines. It is interesting to note their special cytotoxic activity against NCIADR cell line. © 2006 Elsevier SAS. All rights reserved.
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Rights: fechado
Identifier DOI: 10.1016/j.ejmech.2006.03.006
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-33744966570&partnerID=40&md5=f47d5aa4b3806a1c38a64a09155fd096
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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