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Type: Artigo de periódico
Title: Antiproliferative Effect Of baylis-hillman Adducts And a new Phthalide Derivative On human Tumor Cell Lines
Author: Kohn L.K.
Pavam C.H.
Veronese D.
Coelho F.
De Carvalho J.E.
Almeida W.P.
Abstract: In this work we report our results concerning the study on the in vitro antiproliferative activity of 18 Baylis-Hillman adducts and some derivatives against a panel of humor tumor cell lines. A brief qualitative structure-activity relationship study indicated that carbon-carbon double bond and the presence of an electron-withdrawing substituent at the aromatic ring are essential for the activity. A quinoline-phthalide derivative has exhibited a potent effect on the proliferation of all cell lines. It is interesting to note their special cytotoxic activity against NCIADR cell line. © 2006 Elsevier SAS. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.ejmech.2006.03.006
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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