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Type: Artigo de periódico
Title: Endometrial Histology, Microvascular Density And Caliber, And Matrix Metalloproteinase-3 In Users Of The Nestorone®-releasing Contraceptive Implant With And Without Endometrial Breakthrough Bleeding
Author: Oliveira-Ribeiro M.
Petta C.A.
De Angelo Andrade L.A.L.
Hidalgo M.M.
Pellogia A.
Bahamondes L.
Abstract: Objective: This descriptive study evaluated endometrial histology, microvascular density and caliber, and quantification of matrix metalloproteinase (MMP-3) expression in long-term users of the Nestorone® (NES)-releasing implant who presented or not endometrial breakthrough bleeding (BTB). Methods: Endometrial biopsies were obtained from 32 healthy women with unpredictable BTB. The quantitative analysis was performed only in 20 samples. Results: The mean duration of use of the implant among the 14 women with BTB was 19.6±1.0 months, and the other six women had used the implant for 17.7±2.3 months (mean±S.E.M.). Histological analysis of the endometrial tissue showed a predominance of progestogenic pattern followed by atrophic and proliferative endometrium in both groups. Mucosal breakdown and glandular pseudostratification were observed in half of the cases. Endometrial vascular density was 73.1±10.0 and 57.5±24.1 vessels/mm2, and maximum vessel diameter was 923.3±86.0 and 1038.0±404 μm (mean±S.E.M.) in the group with and without BTB, respectively, without significance, and the rate of cells expressing MMP-3×1000 counted stromal cells was 155.8±24.8 and 127.0±19.0 (mean±S.E.M.) in both groups, respectively, without significance. Conclusions: This study provides information about some endometrial aspects of women using NES in contraceptive implants. In addition, the endometrium was similar during long-term use of NES-releasing contraceptive implants in women with and without endometrial bleeding. © 2006 Elsevier Inc. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.contraception.2005.10.013
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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