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|Type:||Artigo de periódico|
|Title:||Serological Detection Of Anti Hpv 16/18 And Its Association With Pap Smear In Adolescents And Young Women [detecção Sorológica De Anti-hpv 16 E 18 E Sua Associação Com Os Achados Do Papanicolaou Em Adolescentes E Mulheres Jovens]|
Mauricette Derchain S.F.
De Oliveira E.Z.
|Abstract:||OBJECTIVE. Verify the relation between HPV 16/18 antibodies and the association with cervical cytology findings in adolescents and young women. METHODS. A cross sectional study with 541 healthy and sexually active women from 15 to 25 years of age was carried on from September to November 2000. At gynecological examination, a cervical sample on liquid-base for cytology-testing and a bblood sample for ELISA identification of HPV 16 and 18 antibodies were collected and sent to a reference laboratory in Belgium. Statistical analysis estimated the prevalence and prevalence ratio with a 95% confidence interval. RESULTS. Of these young women, 150 (27.7%) were seropositive: 79 (14.6%) to HPV 16 antibody; 35 (6.4%) to HPV 18 antibody and 36 (6.6%) to both HPV 16/18 antibodies. Cytological abnormalities were detected in 107 cases (20.5%): 63 presented with atypical squamous cells of undetermined significance (ASCUS), 41 were suggestive of low grade squamous intra-epithelial lesion (LGSIL) and 3 of high grade squamous intra-epithelial lesion (HGSIL). Prevalence of abnormal cytology with a positive serology was only 1.75 times that of prevalence of abnormal cytology with a negative serology. Detection of abnormal cytology was not correlated with positive serology. CONCLUSION. Results of this study indicate a high prevalence of HPV 16 and 18 in young healthy women which showed no relation to the abnormal findings of cytology smears.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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