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Type: Artigo de evento
Title: Cardiovascular Pharmacogenetics [farmacogenética Cardiovascular]
Author: Sandrim V.C.
Rezende V.B.
Tanus-Santos J.E.
Abstract: The widely acknowledged variability in drug response is partiality due to differences in genetic background. Pharmacogenetics is a branch within the field of Clinical Pharmacology focused on the study of how genetic differences affect drug responses. Genetic variations (called polymorphisms) may change pharmacokinetic parameters (by altering enzymes involved in drug metabolism), and pharmacodynamic parameters (by altering receptor affinity by agonist and antagonist drugs). Presently, pharmacogenetics has been valued as a potentially useful tool in finding better therapeutics. This review is mostly concerned with cardiovascular pharmacogenetics. Clinical cases will be described and their possible pharmacogenetic implications will be briefly commented on.
Rights: aberto
Identifier DOI: 
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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