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|Type:||Artigo de periódico|
|Title:||L-arginine Enhances Muscle Regeneration After Experimental Envenomation By B. Jararacussu: A Future For Nitric Oxide-based Therapy?|
|Abstract:||We investigated whether muscle fiber regeneration would be rescued by exogenous administration of l-arginine, the precursor of endogenous synthesis of nitric oxide. The right tibialis anterioris muscle of adult mice (n = 20) was injected with 80 μg of venom. One group of mice (n = 10) received drinking water containing l-arginine (3.75 mg/ml) and another group (n = 10) did not receive any pharmacological treatment. Two months later, muscle regeneration was evaluated by counting the total number of muscle fibers. We found that in l-arginine-treated mice, muscle regeneration was significantly higher (p < 0.05) than in saline-treated (2.230 ± 478 muscle fibers versus 1.005 ± 134, respectively) although the level of muscle fiber population of uninjured tibialis anterioris muscle (3.121 ± 102) was not attained. These results show that muscle regeneration was significantly facilitated by l-arginine and suggest that pharmacological activators of the NO pathway may be potentially useful for improving muscle regeneration in human envenomation by B. jararacussu. © 2006 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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