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|Type:||Artigo de periódico|
|Title:||In Vitro Studies On The Release Of Isoniazid Incorporated In Poly(ε-caprolactone)|
De Oliveira A.F.
De Azevedo M.M.M.
|Abstract:||A polymeric micro- and nanosphere formulation using poly (ε-caprolactone) (PCL) to entrap an antituberculosis drug, isoniazid (INH), was developed and characterized. The microspheres were prepared by a solvent evaporation method using ethyl acetate, PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. The nanospheres were prepared by a spontaneous emulsification solvent diffusion method using 40% ethanol in acetone (v/v), PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. After freeze-drying, these systems were characterized by scanning electron microscopy (SEM), particle size analysis, determination of entrapped INH content, in vitro INH release and brine shrimp toxicity bioassay. © E.S.I.F.T. srl.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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