Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/102773
Type: Artigo de periódico
Title: In Vitro Studies On The Release Of Isoniazid Incorporated In Poly(ε-caprolactone)
Author: Duran N.
De Oliveira A.F.
De Azevedo M.M.M.
Abstract: A polymeric micro- and nanosphere formulation using poly (ε-caprolactone) (PCL) to entrap an antituberculosis drug, isoniazid (INH), was developed and characterized. The microspheres were prepared by a solvent evaporation method using ethyl acetate, PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. The nanospheres were prepared by a spontaneous emulsification solvent diffusion method using 40% ethanol in acetone (v/v), PCL and INH as the organic phase and water and Tween 40 as the aqueous phase. After freeze-drying, these systems were characterized by scanning electron microscopy (SEM), particle size analysis, determination of entrapped INH content, in vitro INH release and brine shrimp toxicity bioassay. © E.S.I.F.T. srl.
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Rights: fechado
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-33751195252&partnerID=40&md5=0588a9d899eebba415026126d111b88b
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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