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Type: Artigo de periódico
Title: Pycnogenol® Protects Against Ionizing Radiation As Shown In The Intestinal Mucosa Of Rats Exposed To X-rays
Author: Ramos F.M.D.M.
Schonlau F.
Novaes P.D.
Manzi F.R.
Boscolo F.N.
De Almeida S.M.
Abstract: X-rays and gamma radiation delivered to the abdominal region for cancer treatment encompasses severe damage to the intestinal mucosa, which significantly impairs a patient's quality of life. To a great extent the deleterious effects of x-radiation originate from radiolysis-induced reactive oxygen species. The well-researched powerful antioxidant Pycnogenol® was administered orally to rats prior to x-irradiation with 15 Gy. Histological sections of the intestines showed a dramatically better condition of the mucosal layers compared with the irradiated control animals administered water without Pycnogenol®. Pycnogenol® treatment significantly preserved the height and number of villi as well as the glandular layer and a diminished number of congested vases were present. No intestinal alterations were seen in control animals receiving Pycnogenol® in the absence of radiation. It is concluded that Pycnogenol® provides significant protection from ionizing radiation damage. Copyright © 2006 John Wiley & Sons, Ltd.
Rights: fechado
Identifier DOI: 10.1002/ptr.1934
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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