Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/102766
Type: Artigo de periódico
Title: E. Coli Virulence Factors In Children With Neurogenic Bladder Associated With Bacteriuria
Author: Guidoni E.B.M.
Dalpra V.A.
Figueiredo P.M.
da Silva Leite D.
Mimica L.M.J.
Yano T.
Blanco J.E.
Toporovski J.
Abstract: The value of E. coli virulence factors in patients with neurogenic bladder has not been established. The aim of this study is to correlate E. coli virulence factors with asymptomatic and symptomatic UTI in children with neurogenic bladder. Fifty E. coli strains, which were collected in sequence, underwent analysis in relation to: The association to pyuria, serotype (O:H), the presence of genes and expression of fimbriae P, type 1, S and hemagglutinin Dr, the presence of the gene and production of hemolysins and cytotoxins (CNF1). We also analyzed the cell adherence capability and pattern and presence of usp (uropathogenic-specific protein). Pyuria was present in most of the positive urine cultures, with 86% AB and 97% UTI. Low rates of uropathogenic strains were observed in the two groups, with 18% AB and 21% UTI. Type 1 fimbria predominated in 44% of the E. coli strains. Of the bacteria studied, 30% (15 strains) exhibited papG genotypes (11 class II and 4 class III). Of these, 12/15 patients presented AB. Production of hemolysins was detected in 38% of the strains (16 AB and 3 UTI) and usp in only 18% of the strains, with 8 AB and 1 UTI. Adherence tests demonstrated the adhesive capacity in all samples analyzed. Neither group (AB or symptomatic UTI) presented a statistically significant difference in relation to the virulence factors studied. E. coli clones that caused symptomatic UTI in children with neurogenic bladder expressed few virulence factors, with no statistically significant difference in comparison to the AB group. © IPNA 2005.
Editor: 
Rights: fechado
Identifier DOI: 10.1007/s00467-005-2133-0
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-33244472620&partnerID=40&md5=ddb9d56a63a10160dec8a3d70f3528b5
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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