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Type: Artigo de periódico
Title: Venous Endothelial Dysfunction In Chagas' Disease Patients Without Heart Failure [disfunção Endotelial Venosa Em Pacientes Com Doença De Chagas Sem Insuficiência Cardíaca]
Author: Plentz R.D.M.
Irigoyen M.C.
Muller A.S.
Casarini D.E.
Rubira M.C.
Moreno Jr. H.
Mady C.
Ianni B.M.
Krieger E.M.
Consolim-Colombo F.
Abstract: OBJECTIVE: To analyze the venous endothelial function in Chagas' disease patients without heart failure. METHODS: The Chagas' disease Group (G1) was composed by 14 women and 2 men aged 46 ± 2,7 and the Control Group (G0) by 7 women and 1 man matched by age, weight and height. Dorsal Hand Vein Compliance Technique was used to evaluate the venous endothelial function. Crescent doses of phenylephrine were infused to get a 70% preconstriction of the vein; after that, acetylcholine and sodium nitroprusside were respectively administrated to analyze the endothelium-dependent and -independent venodilation. RESULTS: No significant systemic hemodynamic changes were observed in both groups during the experiment. The necessary phenylephrine dose to reach 70% preconstriction of the vein was significantly higher in the G1 (1116 ± 668,2 ng/ml) compared to G0 (103 ± 28 ng/ml) p = 0,05. The endothelium-dependent venous dilation was significantly lower in G1 (65,5 ± 8%) compared to G0 (137 ± 20 %) p = 0,009. No difference was observed in the endothelium-independent venous dilatation between groups. CONCLUSION: Patients with Chagas' disease without heart failure presented venous endothelial dysfunction.
Rights: aberto
Identifier DOI: 10.1590/S0066-782X2006000600009
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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