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Type: Artigo de periódico
Title: Do Seizures Promote Mesial Temporal Sclerosis?
Author: Cendes F.
Andermann F.
Abstract: Several studies have shown a significant relationship between a history of prolonged febrile seizures (FS) in early childhood and mesial temporal sclerosis (MTS). However, population based studies have not shown a significant relationship between FS early in life and subsequent temporal lobe epilepsy (TLE). The interpretation of these observations remains controversial. One possibility is that the early FS damages the hippocampus and is therefore a cause of MTS. Another possibility is that the child had a prolonged FS because the hippocampus was previously damaged due to a prenatal or perinatal insult or to a genetic predisposition. Recent studies have shown that prolonged and focal FS can produce acute hippocampal injury that evolves to hippocampal atrophy and that complex FS can actually originate in the temporal lobes in some children. MRI studies in familial TLE demonstrated evidence of MTS in patients with benign epilepsy and seizure remission, or even individuals who had a single seizure, suggesting that the relationship between MTS and severity of TLE might be more complex than previously suspected. MTS most likely has different causes and results from complex interactions among genetic and environmental factors.
Rights: aberto
Identifier DOI: 
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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